Genome-wide analysis of over 106 000 individuals identifies 9 neuroticism-associated loci

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IMMEDIATE COMMUNICATION Genome-wide analysis of over 106000 individuals identifies 9 neuroticism-associated loci

Neuroticism is a personality trait of fundamental importance for psychological well-being and public health. It is strongly associated with major depressive disorder (MDD) and several other psychiatric conditions. Although neuroticism is heritable, attempts to identify the alleles involved in previous studies have been limited by relatively small sample sizes. Here we report a combined meta-ana...

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Genome-wide association analysis identifies novel loci for chronotype in 100,420 individuals from the UK Biobank

Our sleep timing preference, or chronotype, is a manifestation of our internal biological clock. Variation in chronotype has been linked to sleep disorders, cognitive and physical performance, and chronic disease. Here we perform a genome-wide association study of self-reported chronotype within the UK Biobank cohort (n=100,420). We identify 12 new genetic loci that implicate known components o...

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ژورنال

عنوان ژورنال: Molecular Psychiatry

سال: 2016

ISSN: 1359-4184,1476-5578

DOI: 10.1038/mp.2016.49